Bioinspired Origami: Information Retrieval Techniques for Design of Foldable Engineering Applications

The science of folding has inspired and challenged scholars for decades. Origami, the art of folding paper, has led to the development of many foldable engineering solutions with applications in manufacturing, materials, and product design. Interestingly, three fundamental origami crease patterns are analogous to folding observed in nature. Numerous folding patterns, structures, and behaviors exist in nature that have not been considered for engineering solutions simply because they are not well-known or studied by designers. While research has shown applying biological solutions to engineering problems is significantly valuable, various challenges prevent the transfer of knowledge from biology to the engineering domain. One of those challenges is the retrieval of useful design inspiration. In this dissertation work, information retrieval techniques are employed to retrieve useful biological design solutions and a text-based search algorithm is developed to return passages where folding in nature is observed. The search algorithm, called FoldSearch, integrates tailored biological keywords and filtering methods to retrieve passages from an extensive biological corpus. The performance of FoldSearch is evaluated using statistical methods for information retrieval and validated using inter-rater reliability analysis. The utility of FoldSearch is demonstrated through two case studies where the retrieved biological examples undergo a design abstraction process that leads to the development of bioinspired origami crease patterns and novel foldable structures. The design abstraction process is presented as an additional research contribution and demonstrates the potential to provide bioinspired design solutions for the growing research field of origami engineering

Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine

Despite rapid technical progress and demonstrable effectiveness for some types of diagnosis and therapy, much remains to be learned about clinical genome and exome sequencing (CGES) and its role within the practice of medicine. The Clinical Sequencing Exploratory Research (CSER) consortium includes 18 extramural research projects, one National Human Genome Research Institute (NHGRI) intramural project, and a coordinating center funded by the NHGRI and National Cancer Institute. The consortium is exploring analytic and clinical validity and utility, as well as the ethical, legal, and social implications of sequencing via multidisciplinary approaches; it has thus far recruited 5,577 participants across a spectrum of symptomatic and healthy children and adults by utilizing both germline and cancer sequencing. The CSER consortium is analyzing data and creating publically available procedures and tools related to participant preferences and consent, variant classification, disclosure and management of primary and secondary findings, health outcomes, and integration with electronic health records. Future research directions will refine measures of clinical utility of CGES in both germline and somatic testing, evaluate the use of CGES for screening in healthy individuals, explore the penetrance of pathogenic variants through extensive phenotyping, reduce discordances in public databases of genes and variants, examine social and ethnic disparities in the provision of genomics services, explore regulatory issues, and estimate the value and downstream costs of sequencing. The CSER consortium has established a shared community of research sites by using diverse approaches to pursue the evidence-based development of best practices in genomic medicine

Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.

BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden

Bioinspired Origami: Information Retrieval Techniques for Design of Foldable Engineering Applications

The science of folding has inspired and challenged scholars for decades. Origami, the art of folding paper, has led to the development of many foldable engineering solutions with applications in manufacturing, materials, and product design. Interestingly, three fundamental origami crease patterns are analogous to folding observed in nature. Numerous folding patterns, structures, and behaviors exist in nature that have not been considered for engineering solutions simply because they are not well-known or studied by designers. While research has shown applying biological solutions to engineering problems is significantly valuable, various challenges prevent the transfer of knowledge from biology to the engineering domain. One of those challenges is the retrieval of useful design inspiration. In this dissertation work, information retrieval techniques are employed to retrieve useful biological design solutions and a text-based search algorithm is developed to return passages where folding in nature is observed. The search algorithm, called FoldSearch, integrates tailored biological keywords and filtering methods to retrieve passages from an extensive biological corpus. The performance of FoldSearch is evaluated using statistical methods for information retrieval and validated using inter-rater reliability analysis. The utility of FoldSearch is demonstrated through two case studies where the retrieved biological examples undergo a design abstraction process that leads to the development of bioinspired origami crease patterns and novel foldable structures. The design abstraction process is presented as an additional research contribution and demonstrates the potential to provide bioinspired design solutions for the growing research field of origami engineering

Reporting on Climate Change: Understanding the Science, Third Edition

The Environmental Law Institute, the grantee, in the final quarter of operation under Department of Energy Grant DE-FG02-02ER63414, successfully completed the following tasks associated with the grant: (1) published ''Reporting on Climate Change: Understanding the Science'', the third edition of this resource intended primarily to help print and broadcast journalists report more effectively on scientific aspects of global climate change; (2) distributed the reporters guide directly to roughly 500 journalists and journalism educators participating in the annual meeting of the Society of Environmental Journalists in New Orleans, La.; (3) distributed the reporters guide to an additional 1,500 journalists and journalism educators by mail; (4) provided journalism educators bulk copies, upon specific request, for their use in upper-level science journalism and environmental journalism classes; (5) conducted outreach to science editors and environmental reporters on availability and use of the reporter's guide; (6) completed financial reporting associated with the reporter's guide grant. ELI has provided requested bulk numbers of copies of ''Reporting on Climate Change: Understanding the Science'' to the DOE Project Officer, David C. Bader, Ph.D., and to Jeffrey Amthor, Ph.D., in the Office of Science. ELI currently has a remaining inventory of roughly 500 copies from the original printing of more than 3,000 copies of the guide. These copies are used for responding to continuing requests from journalists and educators for the guide. ELI is currently exploring opportunities for reprinting additional copies to help meet the continuing demand from the educational and journalism communities